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Image Search Results
Journal: bioRxiv
Article Title: Divergent use of metabolic fluxes in breast cancer metastasis
doi: 10.1101/2020.08.03.234468
Figure Lengend Snippet: A) RNA expression of LDHA and LDHB in BrM2 vs parental cells. LDHA: 1.5-fold, p=0.3, LDHB: 1.1-fold, p=0.3. Data are represented as mean ± SD. B) RNA expression of LDHA and LDHB in LM2 vs parental cells. LDHA: .9-fold, p=0.7. LDHB: 1.4-fold, p=0.02. Data are represented as mean ± SD. C) Boxplot of ratio of LDH genes (sum of LDHA and LDHB) to PDH genes (sum of PDHA1 and PDHA2) in cell lines. Fold change relative to parental: BrM2: 1.2-fold, p=0.2, LM2: 1.5-fold, p=0.007. Fold change LM2/BrM2: 1.3-fold, p=0.03. D) Boxplot of ratio of LDH genes to PDH genes in patient tumors from The Metastatic Breast Cancer Project. The “Lung” classification includes all tumors that had lung metastases, “Brain” classification includes all tumors that had brain/CNS metastases, and “Other” classification contains tumors that had metastases other than to the lung or brain/CNS. Fold change lung/other: 1.6-fold, p=0.02. See also Fig S5.
Article Snippet: The ratio of gene expression of (LDHA+LDHB)/(PDHA1+PDHA2) was calculated for each patient;
Techniques: RNA Expression
Journal: Briefings in Bioinformatics
Article Title: Detection call algorithms for high-throughput gene expression microarray data
doi: 10.1093/bib/bbp055
Figure Lengend Snippet: Using the Illumina detection method, frequency and percent of detection calls by spike-in concentration for the Illumina spike-in dataset using Illumina recommended thresholds of α = 0.01 and α = 0.05
Article Snippet: Right panel: Boxplots of P -values from two-sample t -test comparing mean bead-level expression to negative control expression by spike-in concentration for the
Techniques: Concentration Assay
Journal: Briefings in Bioinformatics
Article Title: Detection call algorithms for high-throughput gene expression microarray data
doi: 10.1093/bib/bbp055
Figure Lengend Snippet: When comparing bead-level intensities for each beadtype to the bead-level intensities of negative control beadtypes using a two-sample t -test, frequency and percent of detection calls by spike-in concentration for the Illumina spike-in dataset using Illumina recommended thresholds of α = 0.01 and α = 0.05
Article Snippet: Right panel: Boxplots of P -values from two-sample t -test comparing mean bead-level expression to negative control expression by spike-in concentration for the
Techniques: Negative Control, Concentration Assay